Benzene to m-nitroacetophenone
2 steps: Friedel-Crafts acylation, then substitution
BenzeneC₆H₆Arene - Step 1
CH₃COCl, anhydrous AlCl₃
AcetophenoneC₆H₅COCH₃Ketone - Step 2
conc. HNO₃ + conc. H₂SO₄
m-Nitroacetophenonem-O₂NC₆H₄COCH₃Ketone
Exam answer
- Step 1: Benzene to acetophenone: CH₃COCl, anhydrous AlCl₃.
- Step 2: Acetophenone to m-nitroacetophenone: conc. HNO₃ + conc. H₂SO₄.
Reagent and reason, step by step
- Step 1: Benzene to acetophenone: CH₃COCl, anhydrous AlCl₃ Friedel-Crafts acylation: the acyl group deactivates the ring, so it stops at one substitution.
- Step 2: Acetophenone to m-nitroacetophenone: conc. HNO₃ + conc. H₂SO₄ The acetyl group is meta directing, so nitrate after acylation to get the meta isomer.
Benzene to m-nitroacetophenone: quick answers
How many steps does it take to convert benzene to m-nitroacetophenone?
2 steps: Benzene, then acetophenone, then m-nitroacetophenone.
Which named reaction is used to convert benzene to m-nitroacetophenone?
Friedel-Crafts acylation. Benzene reacts with an acyl chloride or anhydride in the presence of anhydrous AlCl3 to give an aromatic ketone.
What is the reagent for step 1 of benzene to m-nitroacetophenone?
Benzene to acetophenone: CH₃COCl, anhydrous AlCl₃. Friedel-Crafts acylation: the acyl group deactivates the ring, so it stops at one substitution.